The excerpts below were obtained from a 2022 Journal of Biol…

The excerpts below were obtained from a 2022 Journal of Biological Chemistry publication called “Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants”. The paper reports that Omicron P132H mutations leave nirmatrelvir potency largely unchanged. What structural rationale is most consistent with this finding?

The information below is an excerpt from a 2025 publication…

The information below is an excerpt from a 2025 publication in Nature titled “Structural and functional characterization of human sweet taste receptor”. Certain T1R2 VFT mutations shift EC50 values for multiple sugars in parallel. What structure–function conclusion is most consistent with this pattern?