37. Alpha-1-antitrypsin (A1AT) is a protein secreted from th…

37. Alpha-1-antitrypsin (A1AT) is a protein secreted from the liver to counteract and inhibit the neutrophil enzyme Elastase. Elastase is used to destroy bacteria and debris in the lungs. Misfolding of the A1AT protein can lead to decrease liver secretion and increase Elastase function—leading to the destruction of tissue surrounding the alveoli. Which of the following would be symptomatic of misfolded A1AT?

49. Peter experiences some shortness of breath during modera…

49. Peter experiences some shortness of breath during moderate levels of activity. He is checked out by a physician and is told his lungs and heart appear to be fine, but he is sent for more testing.  He goes through some respiratory diagnostic procedures that result in the following information: Given this information, calculate Peter’s vital capacity in mL Inspiratory capacity – 3865 mL Inspiratory reserve volume – 3400 mL Expiratory reserve volume – 950 mL Respiratory rate – 14 breaths/min

30. An elderly patient with end-stage COPD comes to his pulm…

30. An elderly patient with end-stage COPD comes to his pulmonologist because of breathing difficulties during daily tasks due to allergies. The doctor decides to place the patient on mechanical ventilation to manage this exacerbation of symptoms. What would be the appropriate ventilation strategy for this patient?

52. I have not received a previous version of this exam for…

52. I have not received a previous version of this exam for studying purposes. I will not share this exam with any previous or incoming students. I acknowledge that receiving or sharing graded materials is a violation of the academic integrity policy set forth by the CWRU School of Graduate Studies.

16. A 67-year-old male is brought in by EMS after being foun…

16. A 67-year-old male is brought in by EMS after being found unconscious on the first floor of a burning building. On exam, his respiratory rate is 14 breaths/min with scattered wheezes. He has no evidence of any burns, but dark soot is caked around much of his face. Suspecting CO inhalation injury, you expect this man’s oxygen-hemoglobin curve will be: