A 58-year-old woman with a history of hypothyroidism presents with facial puffiness, coarse dry skin, and hoarseness. Her TSH is elevated, and free T4 is low. What is the most likely explanation?

A 52-year-old male presents with chest tightness, diaphoresis, and ECG changes consistent with a STEMI. His troponin level is significantly elevated. What does troponin elevation indicate?

A 19-year-old male presents with severe abdominal pain and hematochezia. Colonoscopy shows cobblestoning and skip lesions. What is the most likely diagnosis?

A 32-year-old man presents with burning epigastric pain that improves with eating. Urea breath test is positive. What is the most likely diagnosis?

A 74-year-old female with hypertension presents with confusion and a sodium level of 118 mEq/L. She recently underwent hip surgery and has been receiving morphine. Urine is concentrated, and serum osmolality is low. What is the most likely cause of her hyponatremia?

A 49-year-old man undergoing chemotherapy for lymphoma presents with hyperkalemia, hyperphosphatemia, and hypocalcemia. Which condition is most likely responsible?

A 22-year-old patient who weighs 62kg is admitted to hospital after taking an overdose of propranolol tablets. She admits to taking 28 propranolol 40mg tablets. The patient is prescribed intravenous glucagon and given an initial bolus of 10mg over 10 minutes. Following the bolus, she is prescribed an intravenous infusion at a dose of 50microgram/kg/hour for 60 minutes. The glucagon solution used for the infusion is prepared at a concentration of 1mg/mL. How many milligrams of the glucagon will the patient receive in total Give your answer to ONE (1) decimal place.

Whilst conducting an NHS health check, you ask a patient about his alcohol consumption. He tells you he usually drinks two 750mL bottles of wine (12%ABV) spread across the week.   How many units of alcohol is he consuming each week?

A four-year-old patient who weighs 16.8kg is prescribed dexamethasone for croup. The standard dose is 150microgram/kg for one dose.    How many mL of dexamethasone 2mg/5mL liquid should be prescribed for this patient?   Give your answer to ONE (1) decimal place. 

Streptokinase reduces the rate of mortality associated with myocardial infarction from 0.12 to 0.075.  What is the number needed to treat (NNT) for streptokinase to prevent one death from stroke?  ARC = the absolute risk of events in the control group ART = the absolute risk of events in the treatment group ARR (absolute risk reduction) = ARC – ART RRR (relative risk reduction) = (ARC – ART) / ARC  NNT (number needed to treat) = 1 / ARR