A medicinal chemist needs to determine if the peptide bond found in a potential drug is important for rigidity or hydrogen bond formation. Which of the following substitutions for the peptide (amide) bond will show that rigidity is important?

Peptides have several disadvantages as drugs. Which of the following is not a disadvantage?

Considering the three molecules shown to the right. V and VI are variants of combretastatin. Why is analog V is more active than analog VI and combretastatin?   

Which of the following sources has been particularly fruitful in the discovery of antibacterial agents?  

Which of the following properties of a drug is most likely to result in a minimum of side effects?

Which of the following is an enzyme involved in catalyzing Phase II metabolic reactions?

A potential drug needs to be able to bind to a Zn metalloenzyme in order to achieve the desired potency. Which functional group might be the most useful for zinc binding?

Why does the following PL/SQL block fail to execute successfully? DECLARE  v_name1 VARCHAR2(20);BEGIN   DECLARE v_name2 VARCHAR2(20);   BEGIN         DBMS_OUTPUT.PUT_LINE(v_name1);   END;   DBMS_OUTPUT.PUT_LINE(v_name2);END;

Which of the following best describes the role of a wireframe in user interface (UI) design?

What is the parameter mode for p_name in the query_demo procedure in the following PL/SQL block? DECLARE  p_name  persons.name%TYPE;    p_sal   persons.salary%TYPE;BEGIN  query_demo(178, p_name, p_sal);  DBMS_OUTPUT.PUT_LINE(‘Name: ‘ || p_name);  DBMS_OUTPUT.PUT_LINE(‘Salary: ‘ || p_sal);END;