Briefly describe the mechanism by which NF1 protein (neurofibromitosis 1) can down-regulate signaling by receptor tyrosine kinases.
A gene found in a normal cells genome that can be picked up…
A gene found in a normal cells genome that can be picked up and altered by a virus to drive cellular transformation is known as a(n)
Match each drug suffix with the most appropriate description…
Match each drug suffix with the most appropriate description.
Which SH2-containing transcription factor is directly activa…
Which SH2-containing transcription factor is directly activated by JAK tyrosine kinases?
Define Loss of Heterozygosity (LOH) and briefly indicate a g…
Define Loss of Heterozygosity (LOH) and briefly indicate a general example in which LOH would be detrimental to a person.
Hypermethylation of CpG islands is particularly effective at…
Hypermethylation of CpG islands is particularly effective at inactivating tumor suppressor genes when it occurs
Which of the following viruses can cause cancer in humans
Which of the following viruses can cause cancer in humans
TGF-β antagonizes cell proliferation by
TGF-β antagonizes cell proliferation by
TGF-β signaling can inhibit cell entry into the cell divisio…
TGF-β signaling can inhibit cell entry into the cell division cycle. Describe a mechanism by which mitogen signaling through the PI3K/AKT pathway can counteract the inhibitory effects of TGF-β. Be sure to include the factors involved and the specific events that occur in your answer.
Which of the following is associated with an abnormal cell m…
Which of the following is associated with an abnormal cell morphology?