Briefly describe the mechanism by which NF1 protein (neurofibromitosis 1) can down-regulate signaling by receptor tyrosine kinases.

A gene found in a normal cells genome that can be picked up and altered by a virus to drive cellular transformation is known as a(n)

Match each drug suffix with the most appropriate description.

Which SH2-containing transcription factor is directly activated by JAK tyrosine kinases?

Define Loss of Heterozygosity (LOH) and briefly indicate a general example in which LOH would be detrimental to a person.

Hypermethylation of CpG islands is particularly effective at inactivating tumor suppressor genes when it occurs

Which of the following viruses can cause cancer in humans

TGF-β antagonizes cell proliferation by

TGF-β signaling can inhibit cell entry into the cell division cycle. Describe a mechanism by which mitogen signaling through the PI3K/AKT pathway can counteract the inhibitory effects of TGF-β. Be sure to include the factors involved and the specific events that occur in your answer.

Which of the following is associated with an abnormal cell morphology?