You are attempting to develop a vaccine against a bacterium…

You are attempting to develop a vaccine against a bacterium that primarily affects very young children.  This pathogen is armed with a thick, polysaccharide capsule that effectively shields most potential protein antigens.  Your first attempts to develop a vaccine using only the capsule as an antigen failed miserably to induce a robust protective immune response.  A) Why did this vaccine strategy fail? (2pt) B) How would you design a better capsule-based vaccine? Explain your reasoning for why this approach would be more effective.  (2pt)  

How might polymerase chain reaction (PCR) or immunohistochem…

How might polymerase chain reaction (PCR) or immunohistochemistry be used to satisfy one of Koch’s original postulates?  Answers should include a basic description of how the method works (JUST PICK ONE METHOD) and which postulate these methods can be used to address.