You are evaluating a 7 month old infant who presents with pr…

You are evaluating a 7 month old infant who presents with progressive weakness and mild respiratory distress. Parents report he has been healthy other than some recent constipation. On exam you are concerned for poor muscle tone. What history questions are most important for you to ask to assist with determining the diagnosis?

A 6 week old infant presents to the ED with a 2-3 day histor…

A 6 week old infant presents to the ED with a 2-3 day history of poor feeding, decreased wet diapers, and increased sleepiness. On exam you note tacky mucous membranes and a bulging fontanelle. Mom reports the baby has had a fever for the last 2 days that has not really improved with Tylenol. She reports that the baby was born term via vaginal delivery and was discharged home on DOL 2 along with mom. Baby stays at home with mom, has no siblings and no known sick contacts.  Which of the following diagnosis is highest on your differential?