You have just measured your patient’s blood pressure before treatment and received the following results 165/100.  Which of the following terms best describes the results?

Describe the concept of referred pain and give an example.

  Match the correct structure of the knee with the number indicated on the image above.     

Drug Q has a V of 2.0 L/kg. What loading dose (mg) (i.v. bolus) is required to rapidly attain a Cp of 15 mg/liter? 

Which molecule is most likely to get filtered through the glomerular basement membrane?

Drug A, a calcium channel blocker, is 97% plasma protein bound (fup = 0.03); its hepatic plasma clearance is 475 mL/min. Predict the clearance (ml/min) in a patient with hypoalbumenia such that their fup is 0.055. (Use the full equations and do not simplify based on “E” status (i.e low, intermediate or high E).

The clearance of ibuprofen is 4 L/hr and its apparent volume of distribution (V) is 12 liters.  If 800 mg of ibuprofen were administered every 12 hours, what would be the steady-state trough plasma concentration (mg/L)?  Assume rapid and complete absorption that approximates i.v. bolus administration.

Take a deep breath and RELAX

Predict the plasma concentration (mg/L) 3 hours after an oral dose of drug A.  Drug A has the following parameters: Dose = 200 mg F= 0.80 ka = 0.78 hr-1 KE = 0.120 hr-1 V = 50 L

Nexium V = 16 L CLH = 120 ml/min fup = 0.03 Normal Dose is 40 mg daily by mouth (assume all of the drug absorbs and there is no metabolism in the gut) Determine the average steady-state total concentration (mg/L) in a patient with a polymorphism in the CYP2C19 enzyme such that CLint,u is 50% of normal.