Cystic fibrosis (CF) is a genetic disease we will come back…

Cystic fibrosis (CF) is a genetic disease we will come back to periodically. The pathophysiology involves a mutation in the CFTR (cystic fibrosis transmembrane conductance regulator) gene which encodes for a vital chloride channel protein. This leads to mucus blocking primarily the airways and pancreatic ducts (but also other digestive system organs as well as some sweat gland ducts and reproductive system ducts). The reason a dysfunctional chloride channel leads to airway blocking is because without proper chloride transport into the airway lumen___________________.

In most cells (not kidney tubule cells or intestinal absorpt…

In most cells (not kidney tubule cells or intestinal absorptive cells that utilize amino acids like glutamine), glucose that is imported via passive facilitated diffusion through GLUT proteins is rapidly converted within glycolysis to glucose-6-phosphate via the enzyme hexokinase. Beyond one of the end goals of energy production, this also occurs in order to: