Angelica presents with classic migraine headaches occurring…

Angelica presents with classic migraine headaches occurring 8 times per month despite treating with her sumatriptan (Imitrex, a triptan) maximum dose and ibuprofen. She wonders if she can try something else. She has a history of moderate persistent asthma with periodic exacerbations and allergic rhinitis also. She is not pregnant or breastfeeding and has no history of depression. Her Current Medications include Estrogen-progestin combined oral contraceptive 28 day, one tab by mouth daily Fluticasone (Inhaled corticosteroid) 2 puffs twice daily Flonase (nasal corticosteroid) 1 spray in each nostril daily Albuterol (SABA) 1-2 puffs every 4-6 hours as needed for wheezing or cough Montelukast 10mg daily (leukotriene modifier) Sumatriptan 100mg by mouth at onset of migraine HA, may repeat in 2 hours Ibuprofen 400mg by mouth every 8 hours as needed  You decide to begin prophylactic therapy. From the options below, choose the best approach given her current medications and comorbidities. 

BONUS QUESTION (OPTIONAL) The degree to which fetal exposure…

BONUS QUESTION (OPTIONAL) The degree to which fetal exposure to a drug causes adverse effects depends on timing.  While there is potential risk of adverse drug effects on the fetus throughout pregnancy,  a period during gestation that is identified as a critical period is: