A 45-year-old man presents to the clinic with symptoms of ma…

A 45-year-old man presents to the clinic with symptoms of major depressive disorder (MDD) that have progressively worsened over the past few months. He reports experiencing deep sadness, significant weight loss, early morning awakening, and a marked lack of interest in activities he used to enjoy. He describes his mood as distinctly worse in the morning, and notes that even positive events fail to lift his spirits. Physical activity seems more difficult, and he struggles with feelings of worthlessness. Given the patient’s presentation and history, what is the most likely subtype of MDD that he is experiencing?

A 24-year-old female has been suffering from severe depressi…

A 24-year-old female has been suffering from severe depression for the last 2 years. She is experiencing relief of many symptoms on her current treatment; however, she has residual complaints of physical fatigue, lack of energy, and difficulty concentrating. What pharmacological strategies may be most likely to target these residual symptoms?

For 10 years, a 67-year-old patient with bipolar disorder ha…

For 10 years, a 67-year-old patient with bipolar disorder has been treated with Eskalith (lithium) 900mg daily. When oral hydrochlorothiazide (HCTZ) 12.5mg daily is added for hypertension, the patient develops nausea, vomiting, ataxia, and muscle weakness. The patient’s serum lithium level is 2.1 mEq/L. The interaction of the lithium and the thiazide diuretic has induced