The clearance of ibuprofen is 4 L/hr and its apparent volume of distribution (V) is 12 liters.  If 800 mg of ibuprofen were administered every 12 hours, what would be the steady-state trough plasma concentration (mg/L)?  Assume rapid and complete absorption that approximates i.v. bolus administration.

Take a deep breath and RELAX

Predict the plasma concentration (mg/L) 3 hours after an oral dose of drug A.  Drug A has the following parameters: Dose = 200 mg F= 0.80 ka = 0.78 hr-1 KE = 0.120 hr-1 V = 50 L

Nexium V = 16 L CLH = 120 ml/min fup = 0.03 Normal Dose is 40 mg daily by mouth (assume all of the drug absorbs and there is no metabolism in the gut) Determine the average steady-state total concentration (mg/L) in a patient with a polymorphism in the CYP2C19 enzyme such that CLint,u is 50% of normal.

Drug A is renally eliminated with an ERATIO of 2.1. Additionally, changes in urine pH result in changes in the total renal clearance.  Based on this information which processes must be involved in the clearance of Drug A?

Which of the following does not involve pharmacokinetics?

Drug X is a weak base with a pKa of 6.5. It is primarily eliminated by the kidney and its unionized form is non-polar.  Based on this information.

A drug has a volume of 57 L and a half life of 8 hours. From the answers below, what is maximum possible dosing interval if you wanted to target a peak concentration of 20 mg/L and a trough concentration of 5 mg/L?

Based upon your knowledge of joint structures, which do you think could be more satisfactorily replaced by a prosthetic device—a hip joint or a knee joint? Why?

Nerve impulses pass from neuron to neuron at