Fluroacetate is a potent inhibitor of a citric acid cycle enzyme. Fluroacetate has been used as a poison by ranchers in the West to control coyote populations.  In a mammalian cell, fluroacetate is enzymatically converted to the following molecule: What enzyme would be inhibited by this molecule when used as a substrate?

Spontaneous termination of a pregnancy is considered an abortion if:

In fatty acid β-oxidation, the first catalyzed step is given below. This reaction is most similar to what other reaction that we have studied?  

In the endogenous pathway for plasma lipoprotein transport, what lipoprotein is produced in the liver for delivery of cholesterol and cholesteryl esters to extrahepatic tissues (i.e., muscle, adipose)?

The nurse is monitoring a patient in the active stage of labor. Which conditions associated with fetal compromise should the nurse report?  Select all that apply…

In an experimental system for the study of the electron transport chain, electrons can be supplied by adding ascorbate as an artificial electron donor. When using ascorbate in these experiments it is necessary to include an electron acceptor such as TMPD (an intermediate electron acceptor) that accepts electrons from ascorbate and can then donate electrons to cytochrome c. When using this experimental system it would be possible to transfer electrons directly to which complex?

The compound rotenone has seen wide use as a rat poison. As an inhibitor, rotenone binds and blocks electron transport at Complex I of the electron transport chain (ETC). What are the consequences to electron transport when this inhibitor is introduced into cells?

Crib death of infants when fasting (i.e., when sleeping and not eating – therefore a low blood glucose condition) is also known as sudden infant death syndrome (SIDS). SIDS was often blamed on lack of proper care by the parents of the child. It is now known that a significant number of SIDS cases are caused by a genetic defect in the gene that codes for fatty acyl-CoA dehydrogenase, the enzyme that catalyzes the first step in fatty acid β-oxidation (see question 34 for this reaction). If this enzyme is defective, energy from fatty acids is not available and, in addition, gluconeogenesis is inhibited resulting in severe and life-threatening hypoglycemia (low blood glucose). Why the hypoglycemia?

In a cell when oxygen (O2) is limited, NAD+  levels decrease inhibiting the activities of several enzymes including the PDH complex. What other enzymes would be inhitibed by low levels of NAD+?

In glycolysis, the reaction sequence between dihydroxyacetone phosphate and 2-phosphoglycerate involves all of the following EXCEPT: