Human serum albumin (HSA) is the most abundant plasma protein and a versatile carrier that transports a wide range of ligands. It binds long‑chain fatty acids at multiple high‑affinity sites located across distinct protein subdomains, using hydrophobic pockets and specific hydrogen‑bond/ionic interactions to stabilize the anionic carboxylate headgroups. By buffering and distributing fatty acids between tissues, HSA modulates their bioavailability, prevents micelle formation and toxicity in plasma, and delivers them to cells via reversible, concentration‑dependent binding. The figure below is an excerpt taken from a paper titled “Chain Length-dependent Binding of Fatty Acid Anions to Human Serum Albumin Studied by Site-directed Mutagenesis”, published in 2006 in the Journal of Molecular Biology. The graphs compare the binding of 4 different fatty acids of varying length (octanoate = 8 carbons, decanoate = 10 carbons, laurate = 12 carbons, myristate = 14 carbons in length) to the wildtype HSA and to a mutant HSA they created in the lab (denoted as R410A, which indicates that the amino acid at position 410 in the wildtype protein is normally an R but the researchers intentionally changed it to an A). Given these results, which of the following is an accurate statement?
I am so excited about becoming a Medical Assistant!
I am so excited about becoming a Medical Assistant!
Which biological molecule is composed primarily of carbon, h…
Which biological molecule is composed primarily of carbon, hydrogen, and oxygen in a 1:2:1 ratio (2 PTS)?
The excerpts below were obtained from a 2022 Journal of Biol…
The excerpts below were obtained from a 2022 Journal of Biological Chemistry publication called “Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants”. In Figure 2, nitrogen atoms are colored blue, sulfur atoms are colored yellow, and oxygen atoms are colored red. Nirmatrelvir is known to form a reversible covalent bond to Cys 145. What is the side chain of Cys that is involved in the formation of the covalent bond?
Which connection physically connects the end device to the n…
Which connection physically connects the end device to the network?
You have a box of 12×75 mm culture tubes and the box says th…
You have a box of 12×75 mm culture tubes and the box says they are made of KIMAX glass. These would classed as being what?
In Edgar Allan Poe’s “The Cask of Amontillado,” why does Mon…
In Edgar Allan Poe’s “The Cask of Amontillado,” why does Montresor tell his servants that, even though he will not return until morning, they are not to leave the house?
What is a common potential side effect of Rimadyl/carprofe…
What is a common potential side effect of Rimadyl/carprofen?
What is the term for a decimal system of measurement with ba…
What is the term for a decimal system of measurement with base units for length, mass, and volume?
What factor does depend on population density?
What factor does depend on population density?