List two adverse effects that can occur during interhospital transport.

When SIMV is used for SBT as a weaning method the rate is reduced by increments of _________ breaths/min.

What static compliance and airway resistance is associated with successful weaning?

What is the most common reason for weaning failure?

Patients are not considered ventilator dependent until at least 3 months of ventilator weaning attempts failed.

Dr. Wassarman discovered a genetic suppressor of A-T in his fly model of the disease.   What is the genotype of the suppressor? Choose the letter that corresponds to the correct genotype below.  A. stringmutant / stringwild-type (non-mutant) B. stringmutant / stringmutant C. stringwild-type (non-mutant) / stringwild-type (non-mutant) D. P35mutant / P35wild-type (non-mutant) E. P35mutant / P35mutant   Be careful when you mark your selection because the order of the letters might be mixed-up.

Consider the graph below.   What is the best conclusion from these data?

In class we discussed a paper by Cao et al. that reported on a forward genetic screen designed to find gene mutations that cause age-dependent neurodegeneration. Consider the following two figures from this paper: What conclusion can you draw from these two experiments.

Over-expressing a voltage-gated potassium channel gene (Kcna1) reduces neuronal excitability and can suppress seizures in rodent models of epilepsy. Recently, researchers demonstrated that they could suppress seizures if they over-expressed Kcna1 using CRISPR technology. Based on what you know about CRISPR technology, what did they deliver to cells?

Adolescent rats and humans that experience intermittent alcohol exposure are at greater risk of developing anxiety later in life. When mice are intermittently administered high levels of ethanol during adolescence, what happens to histone acetylation in the Arc enhancer region? In order to decrease anxiety, scientists injected viruses carrying CRISPR components into a brain region associated with anxiety (the amygdala) in mice that had experienced intermittent alcohol exposure in adolescence. What CRISPR components did they inject?