You are a researcher in an exercise physiology lab. At rest,…

You are a researcher in an exercise physiology lab. At rest, you took a blood sample from one of your participants and found an increased level of a krebs/TCA/citric acid cycle enzyme (citrate synthase) compared to their baseline 6 months ago. Which assumption would be reasonable?

Nguyen – Autoimmunity My exam tips:  A brief answer is two…

Nguyen – Autoimmunity My exam tips:  A brief answer is two to three sentences in your answer. There may be more than one correct answer to my question. I am looking for how you best articulate your reasoning to support the answer.  (A)  Pick ONE of your favorite T cell types. Briefly describe how self-tolerance breakdown in central and peripheral tolerance can lead to autoimmunity (5 points).  (B)  Briefly describe the similarities and differences between molecular mimicry and bystander activation. (5 points)

Duarte – Transplantation Immunology In kidney transplantatio…

Duarte – Transplantation Immunology In kidney transplantation, a significant effort is put into reducing organ ischemia times and matching between donors and recipients, prior to transplantation. (A)  Briefly define the three key stages involved in the matching process when identifying a suitable donor kidney for a transplant recipient, and what specific immune responses or incompatibilities the transplant team aims to avoid with each stage. (6 points) (B)  Briefly define one main aspect of how ischemia-reperfusion injury activates the innate immune response and how it contributes to the activation of the recipient’s adaptive immune response and the development of graft rejection. (2 points)

Bayer – Evasion & Subversion of Immune Defenses (A)  Provide…

Bayer – Evasion & Subversion of Immune Defenses (A)  Provide five examples that compare and contrast the immune response to extracellular bacteria, intracellular bacteria, and viruses. (5 points) (B)  Pathogens employ strategies to evade or interfere with the host’s immune response, ultimately allowing them to establish and persist within the host. Briefly define three strategies that pathogens employ to evade the immune system. (3 points) (C)  Briefly describe an effective treatment strategy to stimulate a person’s immune system to produce strong immunity against a latent viral infection. (8 points) The immune response within the tumor microenvironment resembles either tumor elimination or tumor escape. (D)  In the elimination microenvironment, briefly define an immune cell type, their mode-of-action, and how the tumor itself plays a role in immune recognition. (3 points) (E)  In the escape microenvironment, briefly define an immune cell type, their mode-of-action and how the tumor itself plays a role in avoiding immune recognition. (3 points)

A section of DNA has the base sequence shown in #1. A mutati…

A section of DNA has the base sequence shown in #1. A mutation in this DNA strand results in the base sequence shown in #2. What type of mutation does this change represent (missense mutation, point mutation, silent mutation, or frameshift mutation? Support your answer by providing a brief definition of each of the types of mutations. #1   5′ – AGCGTTACCGT-3′      #2  5′-AGGCGTTACCGT-3′