A 46-year-old male with active tuberculosis is to be initiat…

A 46-year-old male with active tuberculosis is to be initiated on the four drugs     regimen of isoniazid, rifampicin, pyrazinamide, and ethambutol. The patient     reports no other co-morbidities except gout. Which of the following pair of     antituberculosis drugs has the potential to exacerbate his gout?