A 3 year old male was admitted to the hospital with scattered petechiae and epistaxis (nosebleeds). The patient had normal growth and no other medical problems other than a bout of chicken pox 3 weeks earlier.  His family history was unremarkable.  Test Value Reference Range PT 11 sec 10-13 sec APTT 32 sec 28-37 sec Platelet count 18,000/ul 150,000-450,000/ul Bleeding time 21 min 2-6 min These clinical and laboratory manifestations are consistent with which condition? 

Plasminogen deficiency is associated with:

You are the technologist reviewing blood smears and notice many of the white cells look like the picture below.  Additional lab results on this patient include a normal platelet count and an abnormal bleeding time, and no aggregation with any platelet agonists.  What is the most probable diagnosis for this patient?  

A prolonged aPTT is corrected with factor VIII-deficient plasma but not with factor IX-deficient plasma.  Which factor is deficient?

Which of the following factors would be affected in a patient taking Coumadin? 

Two children in the same family have recurrent, chronic bruising in multiple sites, repeated long-lasting bleeding into joints and major bleeding after surgery or trauma. Which type of disorder is most likely?

A patient sample is mixed with 5M urea.  After 24 hours, the clot is not fully formed and the supernatant is markedly turbid.  What is the most likely interpretation of this result?

A two year old boy was taken to the physician for severe eczema and epistaxis.  The boy has had a history of recurrent infections and cardiac problems.  Previously, he has been successfully treated with antibiotics for the eczema.  Upon physical examination, the physician noted several bruises on his left upper and right lower extremities along with patches of eczema and dermatitis.  The aunt mentioned that several men in their family had suffered from the same symptoms.  The physician ordered the following tests:   TEST RESULT REFERENCE RANGE WBC 6.0 x 10^3/ul 3.5-11.0 x 10^3/ul PLT 190 x 10^3/ul 150-400 x 10^3/ul PT 12.0 sec 11-13 sec APTT 28 sec 23-32 sec BT 17 min 2-10 min This disorder has a triad pathology. All of the following are included in the triad pathology except:

A patient has developed aspirin tolerance and the physician has started him on Plavix (Clopidogrel) because of a previous acute myocardial infarction (AMI).  How will his laboratory monitoring change?

A lab report shows a thrombin time of 18 sec (RR: 10-15 sec) and a reptilase time of 15 sec (RR: 15-20 sec).  What can you conclude from this?