A prolonged aPTT and PT are corrected when mixed with normal pooled plasma.  Which of the following factors is most likely deficient?

An OB patient has just delivered a baby. Upon physical examination, the patient is febrile and pale.  The physician in charge of his care runs a battery of labs.  The results are below: TEST Patient results Reference Range Prothrombin Time 16.8 sec 11-13 sec INR 3.85 NA Activated Partial Thromboplastin Time 71 sec 23-32 sec Fibrinogen 75 mg/dl 200-400 mg/dl Factor X 22% >50% activity Factor II 21% >50% activity Factor VII 23% >50% activity Factor V 28% >50% activity Factor XII 25% >50% activity Factor VIII 28% >50% activity Factor XI 19% >50% activity Factor IX 30% >50% activity Protein C 5% >50% activity Protein S 8% >50% activity D-dimer 580 ng/ml

A prolonged aPTT is corrected with factor VIII-deficient plasma but not with factor IX-deficient plasma.  Which factor is deficient?

A patient has developed aspirin tolerance and the physician has started him on Plavix (Clopidogrel) because of a previous acute myocardial infarction (AMI).  How will his laboratory monitoring change?

Match the letter to the appropriate clotting factor in the diagram below.  For letters that are found in multiple positions, such as J and K, please follow the diagram exactly as it is written in the lecture (26 points)   

Which of the following disorders is characterized by maternal antigen antibody complexes depositing on the surface of fetal platelets and causing destruction?

Which of the following test results is within the normal range in a patient with classic type I von Willebrand disease?

The electron transport chain (ETC) pathway takes place in in cytoplasm and, therefore, it requires oxygen (O2) as the final electron receiver.

Why is analysis of multimers used in the panel of tests for von Willebrand disease?

A 21-year-old woman presents with a primary complaint of menorrhagia (heavy menstrual flow). Her coagulation screen gives the following results. What disorder is most likely?    TEST RESULT REFERENCE RANGE PT 12.0 sec 11-13 sec APTT 40 sec 22-32 sec Factor VIII 35% 50-150% Platelet count 225,000/ul 150,000-450,000/ul RIPA 34% 50-150%