A 3 day old female newborn baby is brought to the emergency…

A 3 day old female newborn baby is brought to the emergency department because of fever, poor feeding and irritability for 6 hours. She was delivered at home at 39 weeks gestation without complication. Her mother had no prenatal care. The baby’s temperature is 39.8C (103.6F), pulse 172 bpm, respiration rate 58/min, blood pressure 74/45 mmHg. The baby appears lethargic. Which of the following mechanisms is a direct consequence of the cytokines likely being secreted by macrophages in this patient?