A 52 year old female presents to the physical therapist with…

A 52 year old female presents to the physical therapist with a persistent cough, wheezing, low ability to tolerate aerobic exercise and dyspnea. She has a 30 pack year history of cigarette smoking and reports her pulmonary symptoms have been ongoing and consistent for the past 3 months.  Currently she has no other symptoms/signs, unremarkable medical history and all vital signs are within normal limits. Which of the following diseases is most likely?