The excerpts below were obtained from a 2022 Journal of Biol…

The excerpts below were obtained from a 2022 Journal of Biological Chemistry publication called “Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants”. The paper reports that Omicron P132H mutations leave nirmatrelvir potency largely unchanged. What structural rationale is most consistent with this finding?

Excerpts from the paper “Structure and evolution of the Ivy…

Excerpts from the paper “Structure and evolution of the Ivy protein family, unexpected lysozyme inhibitors in Gram-negative bacteria” are presented below. The Ivy–lysozyme interface shows high shape complementarity. Which substitution in Ivy would most plausibly reduce inhibitory potency by introducing steric clash without compensating interactions?

The excerpts below were obtained from a 2022 Journal of Biol…

The excerpts below were obtained from a 2022 Journal of Biological Chemistry publication called “Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants”. The paper reports that Omicron P132H mutations leave nirmatrelvir potency largely unchanged. What structural rationale is most consistent with this finding?

The excerpts below were obtained from a 2022 Journal of Biol…

The excerpts below were obtained from a 2022 Journal of Biological Chemistry publication called “Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants”. In Figure 2, nitrogen atoms are colored blue, sulfur atoms are colored yellow, and oxygen atoms are colored red. Nirmatrelvir is known to form a reversible covalent bond to Cys 145. What is the side chain of Cys that is involved in the formation of the covalent bond?

If blood is put into a collection tube without an anticoagul…

If blood is put into a collection tube without an anticoagulant, allowed to coagulate for 15 minutes, then centrifuged, the fluid part of the blood will be called ___________________. *One word answer. Use all lowercase letters. *Do not add any spaces or punctuation before or after the answer.