You are provided with data from a dose-response experiment c…

You are provided with data from a dose-response experiment conducted on BaF3 pre-B lymphocytes engineered to express either wild-type or mutant forms of Bcr-Abl. The cells were tested in the presence or absence of IL-3. Based on the data, what conclusions can you draw regarding: (a) The efficacy of Gleevec? (b) The impact of the T315I mutation on Bcr-Abl function and drug resistance?   

Choose two metastasis suppressor genes from the provided tab…

Choose two metastasis suppressor genes from the provided table. For each gene, explain how it suppresses metastasis without affecting the growth of the primary tumor. Be specific in describing the mechanism or stage of the metastatic cascade that each gene influences.