In class we discussed the paper, “Optogenetics enables functional analysis of human embryonic stem cell-derived grafts in a Parkinson’s disease model”. The figures below come from that paper. (FYI: Halorhodopsin-EYFP is the same thing as eNpHR3.0-EYFP)   Match each panel (A, B, and C) with the mouse genotype that could be responsible for the data. 

Loss-of-function mutations in the SCN2A gene will most likely cause autism/intellectual disability. 1) 1) This type of mutation will most likely neuronal excitability. 2) If an individual with this type of mutation develops seizures, does it make sense to treat them with a sodium channel blocker?

As shown in the image below, the SCN2a protein is a transmembrane protein that has four homologous domains. Each homologous domain contains six membrane-spanning segments (S1-S6).     Which membrane-spanning segment is made up of amino acids that determine the membrane voltage at which the channel opens?

Which of the following dressings is contraindicated for infected wounds?

Which debridement method is MOST appropriate for a patient who refuses painful procedures?

The patient has a history of neck problems.   The physical therapist would like to set the patient up on cervical traction for a C5-C6 nerve root compression problem. What are the most appropriate settings?

A sequential increase and decrease in intensity of a train of impulses is:

A PTA is preparing mechanical traction for a patient with facet joint hypomobility in the lower lumbar spine. What duty cycle is MOST appropriate?

I would like to have a Bonus point.

What does the nurse suspect Mr. Jones could have based on his presenting symptoms?