A 52-year-old woman with abdominal fullness and mild fatigue…

A 52-year-old woman with abdominal fullness and mild fatigue presents to her primary care physician accompanied by her husband. The patient’s personal history is unremarkable. She has a brother with high blood pressure and cholesterol. The patient’s spleen is palpable.    Patient Results Reference Interval WBC 299.1 4.5-11.0 x 10^9/L RBC 2.9 4.3-5. x 10^12/L HGB 8.8 g/dL HCT 25.2 39-55% MCV 87.0 80-11 fL MCH 30.3 25.4-34.6 pg MCHC 34.9 31-37 g/dL RDW 15.2 11.5-14.5 % PLT 603 150-400 x 10^9/L The patient’s differential showed: 30% neutrophils 2% lymphocytes 1% monocytes 7% eosinophils 10% basophils 14% metamyelocytes 32% myelocytes 4% blasts What is the differential diagnosis?

A 6-year-old girl presented to her pediatrician with her par…

A 6-year-old girl presented to her pediatrician with her parents with a chief complaint of easy bruising, nosebleeds, and petechiae. At 1 year of age, she experienced her first episode of epistaxis and has had several episodes since. There have been no significant infections and she has never traveled outside of the US. The family history is unremarkable.    Patient Results Reference Interval WBC 2.9 4.5-11.0 x 10^9/L RBC 2.24 4.3-5. x 10^12/L HGB 6.5 g/dL HCT 18.7 39-55% MCV 84.9 80-11 fL MCH 29.0 25.4-34.6 pg MCHC 34.7 31-37 g/dL RDW 15.3 11.5-14.5 % PLT 6 150-400 x 10^9/L What is the differential diagnosis? 

A 6-year-old girl presented to her pediatrician with her par…

A 6-year-old girl presented to her pediatrician with her parents with a chief complaint of easy bruising, nosebleeds, and petechiae. At 1 year of age, she experienced her first episode of epistaxis and has had several episodes since. There have been no significant infections and she has never traveled outside of the US. The family history is unremarkable.    Patient Results Reference Interval WBC 2.9 4.5-11.0 x 10^9/L RBC 2.24 4.3-5. x 10^12/L HGB 6.5 g/dL HCT 18.7 39-55% MCV 84.9 80-11 fL MCH 29.0 25.4-34.6 pg MCHC 34.7 31-37 g/dL RDW 15.3 11.5-14.5 % PLT 6 150-400 x 10^9/L What is the differential diagnosis?