Descending modulation contributes to stress-induced analgesia by engaging brainstem opioid circuits.

Which of the following best describes the role of CB1 receptors in descending pain modulation?

Why are peripherally-restricted CB1 agonists being developed?

cells in the RVM decrease firing before a nocifensive response and are antinociceptive.

Why are peripherally-restricted CB1 agonists being developed?

Which condition is most likely to involve increased on-cell activity and reduced off-cell firing in the RVM?

Which brainstem structure serves as the primary integrative hub for descending pain modulation and is densely populated with opioid receptors?

Which of the following best explains the role of FAAH inhibitors in pain control?

On-cells in the RVM are primarily responsible for inhibiting pain transmission.

cells in the RVM increase firing before a pain response and facilitate nociception.