2.  Endothelial dysfunction, broadly defined as an overall r…

2.  Endothelial dysfunction, broadly defined as an overall reduced vasodilation in response to known endothelium-dependent vasodilators, has been associated with reduced availability of nitric oxide.  Describe how reactive oxygen species, superoxide (O2-) in particular, contribute to endothelial dysfunction in arteries?  What are the sources of superoxide in endothelial cells?  What enzymes are critical in buffering superoxide.