A 65-year-old female with a history of severe COPD and coron…

A 65-year-old female with a history of severe COPD and coronary artery disease is intubated for severe acute respiratory distress syndrome (ARDS) in the setting of pneumonia. Despite ventilation with 6 mL/kg tidal volumes and neuromuscular blockade, PaO2:FiO2 remains 85 on FiO2 100%. PEEP is increased from 5 to 10 cm H2O, and mean arterial pressure subsequently decreases from 65 to 45. In what setting is increased PEEP least likely to improve oxygenation and hemodynamics?

Mr. Kalish, a long-time government employee, falsely believe…

Mr. Kalish, a long-time government employee, falsely believed that his supervisor was a communist agent who was putting poison in the employees’ coffee. When Mr. Kalish was referred to a psychologist, he complained that he heard voices in his head which told him about the poison in the coffee. Mr. Kalish is most likely suffering from:

A 56-year-old male with advanced idiopathic pulmonary fibros…

A 56-year-old male with advanced idiopathic pulmonary fibrosis presents to the ICU in respiratory distress. He is put on high flow nasal cannula with 50 L flow, 80% FiO2. ABG obtained has a pH significant for 7.32, PaO2 of 80 mm Hg, PaCO2 of 20 mm Hg, HCO3 of 30. Given his underlying disease, what is the primary physiological aberration leading to the patient’s hypoxemia?