A 1-year-old boy is evaluated for a suspected immune deficie…

A 1-year-old boy is evaluated for a suspected immune deficiency. He has a history since birth of eczema, recurrent rashes, and diarrhea. His white blood cell (WBC) count is 6.75/uL (normal values: 5.0–10.8 × 103 uL) with a normal differential. His platelet count is 35,000 (normal values: 150,000–350,000/uL), and the platelets are small. His IgG is 750 mg/dL (normal values: 600–1,500 mg/dL); IgM is 30 mg/dL (normal values; 75–150 mg/dL); IgA is 475 mg/dL (normal values: 50–125 mg/dL); IgE is 750 mg/dL (10–50 mg/dL). The boy’s blood is typed as O-positive, and he does not have anti-A or anti-B antibodies. Flow cytometry performed on his blood shows 11% CD19 (normal values: 5%–20%) and 50% CD3 cells (normal values: 60%–80%) with a normal ratio of CD4:CD8. T-cell function tests are abnormal. This boy most likely has:

A 40-year-old female patient has increased thyroid-stimulati…

A 40-year-old female patient has increased thyroid-stimulating hormone (TSH) and decreased T4 levels with a normal T3 level. Antithyroglobulin is measured as 1:1,280, and the antimicrosomal level is reportedly 1:6,400. This disease is characterized by hypoactivity of the thyroid with weight gain and a sluggish metabolism as a result of destruction of thyroglobulin. This patient most likely has: