A colleague’s tumor biopsy results are released on MyChart p…

A colleague’s tumor biopsy results are released on MyChart prior to their next visit and reflect the following staging and grading: T2, N3, M0 (Stage 3); Grade 4. They understand the staging but ask if you could explain what a Grade 4 tumor is. You know a Grade 4 tumor means: 

A 60-year-old patient with a 10-year history of ulcerative c…

A 60-year-old patient with a 10-year history of ulcerative colitis, an inflammatory bowel disease, presents with recent weight loss, fatigue, and low-grade fever. Labs show elevated C-reactive protein and erythrocyte sedimentation rate. Which of the following best describes the pathophysiological basis of their symptoms?