A 24 yo man presents with the acute onset of chest discomfor…

A 24 yo man presents with the acute onset of chest discomfort. The pain began last night and is substernal and sharp, and non-radiating. The pain is less when the patient is sitting versus lying flat, and is a bit worse with coughing. He has an upper respiratory infection that began 8 days ago, with some mild fevers. On exam his vitals are stable, he is afebrile, and there appears to be a friction rub on cardiac auscultation. What is the most likely diagnosis?

A 10 year old girl with sickle cell disease received a blood…

A 10 year old girl with sickle cell disease received a blood transfusion. It significantly increased her blood volume above normal levels. What changes in inotropy and total peripheral resistance (TPR) would occur within minutes of receiving the blood transfusion?