The following is the mechanism of action of proguanil:                                                            1.        It inhibits the detoxification of the heme in the erythrocyte2.        Its metabolites produce reactive oxygen species which are fatal to the malaria parasite3.        Its metabolites inhibit nucleic acid synthesis by oxidizing plasmodial DNA4.Inhibits plasmodial protein synthesis by binding to 30S ribosomal subunits5.        It inhibits plasmodial dihydrofolate reductase enzyme action

The following statement is true concerning HIV resistance to protease Inhibitors:    High-level resistance occurs to the reverse transcriptase enzyme.It occurs as an accumulation of stepwise mutations of the protease gene.It occurs to prevent allosteric inhibition of the reverse transcriptase enzyme.Resistance occurs as four specific substitutions of the integrase gene.A single-point mutation occurs within the integrase gene.

Match the following drugs with the relevant adverse effects Each drug may be used more than once or not at all:   

Match the following drugs with the relevant adverse effects. Each drug may be used more than once or not at all:

A child is admitted to the pediatric unit with increased secretions, cough, and  nasal drainage.  Physician diagnoses the child with RSV.   A priority nursing diagnosis would be:

A newborn is being discharged to home.  The nurse is setting up a referral to see a Pulmonology specialist to rule out Cystic Fibrosis (CF).  What is the earliest recognizable clinical manifestation of CF?

You are working with a family with and a child who has a congenital heart defect.  Future surgery is planned and you are teaching the parent how to reduce cardiac demands.  The parent needs more teaching when she says  which of the following?

A relatively small number of genes appear to account for much of the variation in skin color observed in humans. Two genes that have undergone positive selection in northern latitudes are OCA2 in Asian populations and SLC24A5 in European populations. In the ancestral African population, the SLC24A5 gene produces a protein with an alanine at amino acid position 111. In the European population the amino acid at position 111 is threonine. The protein that is produced from the SLC24A5 gene exchanges an ion of Na+ from the cell cytoplasm for a Ca2+ ion on the outside of the cell. This exchange appears to be necessary for normal melanin synthesis. In East Asian populations, the OCA2 gene produces a protein with the amino acid arginine at position 618 whereas the ancestral amino acid at that position is histidine. For both genes, the mutation arises from a single base change called a Single Nucleotide Polymorphism The mutations in the SLC24A5 gene affects protein expression in ___________________ while the pigments produced and secreted from these cells are taken up by __________________.

Binding of a hormone to the receptor depicted in the accompanying figure would cause the receptor to bind __________ near its carboxy terminus.  

Covalent bonds are formed between amino and carboxy groups in proteins by: