Q45. A Golden retriever (photo ‘A’) has cutaneous histiocyto…

Q45. A Golden retriever (photo ‘A’) has cutaneous histiocytosis, an inflammatory Lymphohistiocytic proliferative disorder that primarily involves skin and subcutis. Lesions may disappear spontaneously or regress and appear at new sites simultaneously. A biopsy of the skin (see photomicrograph ‘B’) reveals cells that are on IHC and express CD1, CD11c, MHC class II, CD4, and CD90. On transmission EM (see photomicrograph ‘C’), the tumor cells contain Birbeck granules comprised of antigen-bound Langerin (Langerin is a c-type lectin). Which of the following types of immune cells is most likely responsible for the inflammatory infiltrate in this dog? 

You are mapping a gene associated with a Mendelian disease,…

You are mapping a gene associated with a Mendelian disease, and you observe that every member of a large family afflicted with the disease shares the same RFLP pattern at a position on Chr. 11. Every member who doesn’t have the disease has a different RFLP pattern at that same position on Chr. 11. What is the next step?

A genome wide association study of 270,000 SNPs identifies a…

A genome wide association study of 270,000 SNPs identifies a SNP of interest on Chr 9. In a population of individuals with inflammatory bowel disease, 82% of the people have a Thymine and 18% have a Guanine. In the control population, 27% of the people have an Thymine and 73% have a Guanine. The Thymine SNP on Chr 9 has an OR of 2.3. The difference in the SNP frequencies between the case and control population has a p value < 5 x 10-12.  In one sentence or in just a few words, what can researchers conclude about this result? 

A nurse is reviewing orders for a newly admitted patient for…

A nurse is reviewing orders for a newly admitted patient for pneumonia.  The patient also has type 1 diabetes.  Blood sugar has been observed at the 200’s mg/dL level. The medications listed below are the only medications the provider ordered.  What is the nurse’s best action?   Vital signs: BP:  130/80 Heart rate:  110 Temperature:  102 F (oral) Pulse Ox:  94% Respiratory rate:  22  Medications: Azithromycin Lisinopril Metformin Acetaminophen