MHC restriction:

What is present during the first checkpoint in B-cell maturation?

How many hypervariable regions (HV’s) does the (a) alpha chain of a T-cell receptor have?

What is present during the first checkpoint in B-cell maturation?

Which of the following is true about the pre-B-cell?

Successful rearrangement of ______ leads to the deletion and inactivation of the ______ due to its location.

In which of the following stages are the Ig genes for the light chain still in their germline configuration?

Successful rearrangement of ______ leads to the deletion and inactivation of the ______ due to its location.

Imagine you’re a doctor and you discover your infant, recently born patient has thrush. You order genetic sequencing and find that the RAG-1 gene doesn’t produce a functional enzyme.  From what you have learned in this class and with this information at hand, you can conclude that:

Once expression of RAG-1 and RAG-2 genes are turned on, expression is never turned off.