You create a stable transgenic line of flies with an overexp…

You create a stable transgenic line of flies with an overexpression transgene that causes Ultrabithorax (Ubx) overexpression in the 2nd thoracic segment of a fly (“T2” in brown). Below is shown a wild type fly and a summary of some key genetic interactions that usually occur. Evaluate whether each statement below represents a logical outcome of this modification to T2 (true or false). Antp transcription will be inhibited in T2. Antp transcription will be released from inhibition in T3. Antp products will switch from promoting wing fate to haltere fate. T2 will grow a haltere instead of a wing. T3 will grow a wing instead of a haltere.

Which of the following statements about epigenetic inheritan…

Which of the following statements about epigenetic inheritance are true? Select true or false for each statement.  Imprinting occurs when males and females downregulate unique sets of genes by promoter methylation. Methylation resulting from imprinting is erased and reset in the germ line each generation. Some methylation events have been shown to demonstrate significant heritability. Following DNA replication, hemimethylated DNA is targeted by DNA methyltransferase 1 (DNMT1) to restore methylation patterns to the newly synthesized strand. A highly condensed chromatin state (heterochromatin) can “spread” on a chromosome, causing descendant cells to sometimes exhibit phenotypic differences because one or more genes are no longer expressed as strongly.

Below is shown a simplified hypothetical organism, eggman. Y…

Below is shown a simplified hypothetical organism, eggman. You are researching gene1, and intend to create a transgenic eggman line that constitutively overexpresses gene1 across all regions of its body throughout development. Given the scheme below, describe the smallest/simplest transgene that could be added to the eggman genome to accomplish expression of gene1 throughout the entire body of eggman. Your answer should interfere with other genes as little as possible, and your answer does not need to name components related to genomic integration methods, only the functional transgene locus that could drive gene1 expression throughout eggman. Reminder about how eggman works: four transcription factors (magenta, yellow, green, and blue) are all maternally deposited in the pattern shown in the drawing on the left. Those transcription factors (TFs) bind enhancers corresponding to their color (“E” boxes) and drive expression of the head, arm, and leg genes. In this version of eggman, we also have a black transcription factor that is driven by all four maternally deposited TFs, as well as itself. The black TF also drives the expression of an important housekeeping gene that is required for cell survival in eggman.