CAFFEINE SECTION

Select TWO answers that correctly complete the following statement regarding characteristics of P450 enzymes…. *** P450 enzymes generally have _____ substrate specificity to account for the varying chemical composition of drugs

Select the amino acid that can act as both an acid catalyst and a base catalyst in enzyme catalyzed reaction mechanisms.

Caffeine 101: Caffeine (shown here) and theophylline (not shown) are part of a class of naturally occurring compounds known as _____.

Bonus, up to 3pts: SCRATCH PAPER #2: Consider the neurotransmitter acetylcholine shown here. Complete the blanks as directed. *** a) Draw the TWO products of acetylcholine when it is metabolized by acetycholinesterase *** b) Circle the product that can be recycled to produce more acetylcholine in the body

Bonus up to 2 pts: The free phenol group of morphine is important in binding to opioid receptors to relieve pain. Codeine’s phenolic group is masked by a methyl ether. However, when taken orally and absorbed in vivo, useful analgesic properties (i.e., pain relief) is observed. What must be happening to this drug in vivo? Explain…  

Caffeine 101: Caffeine has a pKa of 14. At pH = , caffeine will be 90% Ionized

Consider the statements regarding an in vitro test. Select only the TRUE statement(s). (select all that apply)

The United States failed to ratify the Treaty of Versailles, which ended WWI.

In March 1911, 146 people died in this tragedy.