Cyclosporin A and rapamycin are each used as T cell immunosu…

Cyclosporin A and rapamycin are each used as T cell immunosuppressants. They share the property of binding to immunophilin molecules in T cells as the initial step in their mechanisms of action. Rapamycin:immunophilin complex binds to and inhibits mTOR. As a consequence,

Mycophenolate mofetil is a cytotoxic drug that is commonly u…

Mycophenolate mofetil is a cytotoxic drug that is commonly used in patients receiving kidney transplants as part of a combination therapy. Studies  performed to assess whether reductions in mycophenolate mofetil dose given to transplant patients have deleterious effects on the transplanted kidney function or on episodes of graft rejection. The motivation for this type of study is the