A technologist in a tissue bank who performed HLA typing by DNA analysis was asked to bank all DNA extracted from specimens received in the laboratory so as to maintain the highest quality of nucleic acid for the longest period. How should the DNA be stored to satisfy this request?

Which of the following is the correct order of the stages that occur during cell division?

Mutations in tumor suppressor genes are usually what kind of mutation?

Which of the following translocations is associated with T-cell lymphoma?

A proficiency test (PT) composed of two frozen tissue specimens was received in the molecular laboratory. The specimens were to be tested for the detection of a gene mutation that is part of the laboratory’s current test menu. Because one technologist was off that day and the other staff members were occupied with a large number of patient samples, the supervisor decided to test the two specimens using a modified assay being developed in the laboratory. Because this method was in development, the results of the test were checked against sequencing analysis performed in a blinded manner at a partner institution. The results of the test were recorded on the proficiency documents, signed by the supervisor, and reported to the PT testing agency. When the report from the proficiency agency was received, the laboratory results were consistent with results from other participating laboratories. The laboratory director, however, refused to sign the results.  Why would the laboratory director not accept the proficiency test results? 

Bone marrow is going to be transplanted from a man into his sister. Which of the following laboratory procedures should be performed prior to this transplant to determine the HLA haplotypes of the donor and recipient at the highest resolution?

A child has disputed paternity. The child has the following STR haplotype: TPOX = 7/8; D5S818 = 11/12; D13S317 = 9/10; vWA = 11/12; D21S11 = 27/28. Alleged Father 1 has the following STR haplotype: TPOX = 6/10; D5S818 = 9/13; D13S317 = 9/14; vWA = 14/16; D21S11 = 30/33. What can be said of Alleged Father 1?

Which of the following controls can distinguish between a true-negative in a nucleic acid amplification assay from a false-negative in which amplification failed in the specimen?

A patient is assessed for B-cell clonality by examining the immunoglobulin heavy chain gene rearrangements by PCR using primers complementary to the FR3 and joining regions of the immunoglobulin heavy chain gene. When the products are resolved by gel electrophoresis, the patient lane has a smear and does not have a sharp band. Controls were all acceptable. This result is interpreted as which of the following?

Which of the following organizations has established standards used by laboratory professionals when developing, implementing, and performing molecular-based laboratory tests?