A 7 y/o girl presents with hypertension. Her father and pate…

A 7 y/o girl presents with hypertension. Her father and paternal grandmother developed hypertension before age 20. The AM laboratory studies are presented when she is receiving no medications. Previously DOC (desoxycorticosterone) was reported as within the reference interval. Abdominal CT is negative for adrenal masses. Based on these data, of the following choices, what is the most likely cause of the patient’s hypertension? 

A 74-year old man presents in the emergency room with weakne…

A 74-year old man presents in the emergency room with weakness, back pain and decreased urinary output. His calcium is 13.2 mg/dL (Reference interval: 8.5 – 10.5 mg/dL). The serum creatinine is 1.9 mg/dL (reference interval: 0.5-1.2 mg/dL). His hemoglobin is 11 g/dL (reference interval: 12.5-16.5 g/dL). Two days later a renal biopsy is performed (see image). What is the most likely underlying pathogenesis of this disorder? 

A 32-year old male develops persistent hematuria. A renal bi…

A 32-year old male develops persistent hematuria. A renal biopsy is performed. Light microscopy shows mild mesangial hypercellularity. The image shows a representative image of immunofluorescence staining for IgA. Which statement is true concerning this condition? 

A 68-year old previously healthy male presents with a severa…

A 68-year old previously healthy male presents with a several week history of weight loss and malaise. Laboratory studies reveal increased serum creatinine and markedly increased urinary protein (14 grams/24hours). Monoclonal light chains are detected in the urine. A renal biopsy is performed (see H&E image). IF and EM are being performed. What would be the next best procedure to perform on the biopsy section to make the diagnosis? 

An alcoholic man drinks 10 beers per day and does not eat. N…

An alcoholic man drinks 10 beers per day and does not eat. Note that beer has very little solute (~2 meq/L of Na+; in contrast, Gatorade has 20 meq/L of Na+). He is brought to the ED because his sister (with whom he lives) notes that he is unresponsive except to deep pain. His renal function is normal. Predict his serum sodium concentration (reference interval: 135-145 meq/L) based upon the choices provided.