An adolescent who has asthma and severe perennial allergies…

An adolescent who has asthma and severe perennial allergies has poor asthma control in spite of appropriate use of a SABA and a daily high-dose inhaled corticosteroid. What will the Family Nurse Practitioner do next to manage this child’s asthma? Correct Answer: Refer to a pulmonologist Children older than 12 years who have moderate to severe allergy-related asthma and who react to perennial allergens may benefit from omalizumab as a second-line treatment when symptoms are not controlled by ICSs. The FNP should refer children to a pulmonologist for such treatment. Daily oral corticosteroid medications are not recommended because of the adverse effects caused by prolonged use of this route. Anticholinergic medications are generally used for acute exacerbations during in-patient stays or in the ED. A LABA/ICS combination will not produce different results.

DNA replication can stall as a consequence of the replicatio…

DNA replication can stall as a consequence of the replication machinery encountering hairpin DNA structures that can form due to inverted repeats and palindromic sequences.  When DNA replication stalls, double-strand breaks in the DNA can occur, causing severe genetic and cellular consequences.  Both Werner syndrome (premature onset of age-related phenotypes and cancer) and Bloom syndrome (cancer) are the result of mutations in helicase, an enzyme that unwinds hairpin structures.  Helicase MOST likely breaks which type of bonds in a hairpin?

True-breeding, purple-flowered pea plants were crossed with…

True-breeding, purple-flowered pea plants were crossed with true-breeding, white-flowered pea plants.  The F1 progeny all had purple flowers. If the F1 offspring crossed with true-breeding, purple-flowered pea plants, what would the expected phenotypic ratio of the progeny be?