_______ tolerance to alcohol results from a(n) _______ of liver enzymes.

The _______ index is a measure of drug safety and is calculated by comparing the dose of a drug that produces a particular drug-induced toxic effect in 50% of a given population with the dose of the drug that produces a particular therapeutic effect.

Most illicit drug users are in the _______-year-old age range.

A blood alcohol level of approximately _______% is lethal in half of the population, but because unconsciousness occurs at a BAC of approximately _______%, drinking is often stopped before the lethal level is reached.

The development of _______ in 1858 contributed to the development of “soldier’s disease,” or opiate addiction during the Civil War.

The influx of which ion is crucial for the induction of long-term potentiation?

The gateway theory of drug progression proposes that

A decrease in _______ activity can lead to toxicity, including flushing, nausea, and vomiting.

Depot binding is said to occur when drugs

The first step in the metabolism of ethyl alcohol is its conversion to