Bioethics Case Study Sickle cell anemia is a genetic di…

Bioethics Case Study Sickle cell anemia is a genetic disease caused by a mutation in the beta-globin gene responsible for producing an important subunit of hemoglobin. People that have 2 copies of the mutation have the disease, and those that have 1 copy do not have the disease but are considered “carriers”. At the molecular level, abnormalities in the hemoglobin protein cause it to clump, which leads the red blood cells (rbcs) that carry hemoglobin to become misshapen. As a result, the rbcs cannot bind oxygen as efficiently and the body is deprived of oxygen (anemia). The abnormally shaped rbcs also slow down blood flow and become clogged in narrow blood vessels, causing pain. There is no cure for sickle cell anemia, and the goal of treatment is to manage symptoms. Robin, a 30-year-old female, is a carrier for sickle cell anemia. She recently married Brent, who is also a carrier for sickle cell anemia. They want to start having kids immediately but cannot afford the invasive and expensive assisted reproductive technologies that would ensure them a baby without sickle cell anemia. If they decide to have children naturally, they will have a 1-in-4 (25%) chance of producing a child with the disease. Robin has close relatives who suffer significantly with sickle cell anemia, and she does not want to bring a child into the world with the same difficult fate. Brent is more optimistic and takes the view that they have a 3-in-4 (75%) chance of producing a child that does NOT have sickle cell anemia. Robin does not want to “play the odds” and would prefer to adopt, while Brent feels strongly about having a biological child. Which of the following is an ethical question raised here? Which of the following is a relevant scientific fact to this ethical question? Which of the following is not a stakeholder in how this ethical question gets resolved? Which of the following is not paired with the correct relevant ethical consideration?

Sickle cell anemia is an autosomal recessive disease caused…

Sickle cell anemia is an autosomal recessive disease caused by a mutation in the gene that encodes the hemoglobin protein. Homozygous mutations in this gene lead to the production of mutant hemoglobin protein. When only mutant hemoglobin protein is produced, red blood cells (RBCs) adopt an abnormal sickle shape and their function is impaired. On December 8, 2023 the FDA approved Casgevy to treat sickle cell anemia. Casgevy is the first medical use of the CRISPR-Cas gene-editing system. Casgevy uses CRISPR-Cas9 technology to cut a gene in the genome. What gene is targeted by the Cas9 used in Casgevy?

In dairy cattle, milk yield and compositions are the most im…

In dairy cattle, milk yield and compositions are the most important economical traits. These traits are controlled by genes such as GHR (Growth Hormone Receptor). Your prized cattle, Moostache, has greatly increased milk production, and her genome reveals the variant of GHR that has been associated with increased milk production. A lab collects mammary cells from your prized cattle, Moostache, and uses somatic cell nuclear transfer to clone Moostache. The resulting blastocyst is placed into a surrogate mother to complete develpment and after several months the clone Mini Moostache is born. What type of cloning is this an example of?