Consider the neurotransmitter Dopamine that interacts with dopamine 1 receptors in the body via key interactions with amino acids found in the receptor binding site. If the structure of Dopamine were redrawn properly within the dopamine 1 receptor binding site, match the functional groups (1-5) to the locations in the binding site (A-E) where they would interact. Choices 1-5 may be used once, more than once, or not at all. For example, group 3 typically is found between points (B) and (C). Complete the matching for the remainder of the functional groups. (hint: rotate, twist, flip, turn the molecule as needed…expand combined functional groups as necessary). Functional Group # Binding Site Location (1) phenolic -OH (2) phenolic -OH (3) benzene ring B – C (4) two-carbon spacer (5) primary amine note: Asp114 has a -COOH side chain; Ser194/197 have an -OH side chains

Consider the neurotransmitters shown below. Notice similarities and differences, then answer the questions below *** a) The pharmacophore of these three compounds is best described as: *** b) What is the significance of the “Iso” in the isoprenaline chemical name? *** c) What is the significance of the “NOR” in the noradrenaline chemical name? *** d) If Noradrenaline binds better to “alpha receptors” while isoprenaline binds better to “beta receptors” and Adrenaline binds equally well to both “alpha” and “beta receptors”….              Suggest a STRUCTURE BASED explanation for these differences in selectivity.

Consider the panel of amines. Match the amine with its appropriate chemical classification / description:

Methanol, CH3OH, has a pKa = 15-16. Phenol has a pKa = 10. *** Which is the stronger acid? *** Briefly explain your answer…

Cocaine (a base), has an amine with pKa = 8.61 Fentanyl (a base), has an amine with pKa = 8.3 *** Which is the stronger base? *** Briefly explain your answer…

Honor Code Statement: “The work on this exam is my own and I pledge to not use any outside resources, devices or people to help me.  I pledge that I will not cheat or assist anyone else in cheating”.  Proverbs 10:9 — Whoever walks in integrity walks securely, but whoever takes crooked paths will be found out. Prayer: Philippians 4:6–7 — Do not be anxious about anything, but in every situation, by prayer and petition, with thanksgiving, present your requests to God. And the peace of God, which transcends all understanding, will guard your hearts and your minds in Christ Jesus.

Select ALL the conjugate acid/base pairs from the list below… select all that apply…

The killing of all vegetative pathogens with the exception of spores is called:

How is the flu transmitted?

Which of the following would be considered a vector?