Spleen cells are taken from a mouse immunized with the LCM virus.  2 assays are used to determine antigen-specific functional activity of the spleen cells.   Assay 1: the spleen cells (T cells) are incubated with macrophages that have been briefly exposed to LCM virus (phagocytized the virus), production of IL-2 by the T cells is considered a positive response. Assay 2: the spleen cells are incubated with LCM-infected target cells, lysis of the infected target cells is considered a positive response. The functional activity of which MHC molecules is detected in Assay 1?

What are high endotheilial venules (HEVs)?  Are they involved with lymphocyte or leukocyte extravasation?

List the primary lymphoid organs and summarize their functions in the immune system. (make sure you explain)

Indicate which antibody isotype fits the description:

What are the 3 pathways of complement activation?

Label the Antibody:

In humans and mice, the antibody constant (C) heavy chain gene segments are in which order?

Recombination of immunoglobulin gene segments serves to

What is central tolerance?

How do natural killer cells recognize tumor infected cells?