BCH4024 OC SP25 E3 Q17: A 28-year-old white male complains o…

BCH4024 OC SP25 E3 Q17: A 28-year-old white male complains of severe pain radiating to his left arm and jaw. Although serum triglycerides and HDL (high density lipoprotein) were within the normal range, LDL (low density lipoprotein) cholesterol was 650 mg/dL (normal ~130 mg/dL). You suspect which of the following genetic defects? Which drug would be best to prescribe?

BCH4024 OC SP25 E3 Q21: A three-year-old boy is brought into…

BCH4024 OC SP25 E3 Q21: A three-year-old boy is brought into the clinic suffering from cardiorespiratory distress following an infection. Previously, the boy was admitted to the hospital in a coma and suffered a cardiac arrest. He was extremely hypoglycemic (low blood glucose) and showed hepatomegaly (enlarged liver). Muscle and liver biopsies contained large amounts of lipids.  The diagnosis was a carnitine deficiency. Loss of carnitine will most directly affect which of the following processes?

BCH4024 OC SP25 E3 Q3: Dr. Otto Warburg proposed that cancer…

BCH4024 OC SP25 E3 Q3: Dr. Otto Warburg proposed that cancer cells have an altered metabolism, one that is much more reliant on glycolysis for ATP production, which explains their ability to grow and metastasize. In the 80 years since the “Warburg Hypothesis” was presented, we have learned a lot about the biochemistry of cancer. The following 6 questions are focused on these findings. Another phenotype of many cancer cells is the overexpression of pyruvate dehydrogenase kinase 1(PDK1), the enzyme responsible for phosphorylating the pyruvate dehydrogenase complex. This increase in PDK1 activity would result in which of the following?