Honor Code Statement: “The work on this exam is my own and I pledge to not use any outside resources or people to help me.  By clicking TRUE I pledge that I will not cheat or assist anyone else in cheating”. 

Select the amino acid(s) whose side chain(s) can behave as a nucleophile in biochemical reactions… (select all that apply)

Caffeine 101: Caffeine has a pKa of 14. At pH = , caffeine will be 50% Ionized and 50% UN-ionized

Complete the following statement…. ***  P450 enzymes utilize a -containing ring called “heme” to coordinate with the metal in the active site of the enzyme.

Caffeine 101: Chemically, caffeine can be classified as:  (select all that apply…)

Define (by matching) the letters in the acronym “ADME”. *** A *** D *** M *** E

Caffeine 101: Caffeine’s mechanism of action in the body involves binding to and inhibiting the _____ receptor.

CAFFEINE SECTION

Select TWO answers that correctly complete the following statement regarding characteristics of P450 enzymes…. *** P450 enzymes generally have _____ substrate specificity to account for the varying chemical composition of drugs

Select the amino acid that can act as both an acid catalyst and a base catalyst in enzyme catalyzed reaction mechanisms.