(10 points) Tetanus toxin enters the output regions of motor…

(10 points) Tetanus toxin enters the output regions of motor neurons by endocytosis. The resulting vesicles are transported toward the neuronal cell body on by the end directed motor protein, called . When the vesicle reaches the motor neuron cell body, it is released from this neuron by exocytosis and taken up by endocytosis into inhibitory interneurons. In these interneurons, tetanus toxin destroys VAMP (synaptobrevin), which has alpha helices that span the membrane of . The destruction of VAMP prevents it from winding together with the transmembrane protein and the membrane-associated protein to form the complex. This prevents release of neurotransmitter from the output region of this interneuron and ultimately prevents the opening of channels (be specific for ion type) in the postsynaptic cell. Despite the destruction of VAMP, Ca2+ still enters the cell through calcium channels and binds to on the vesicle membrane.

(10 points) In [a] muscle, which lacks obvious [b], Ca2+ ent…

(10 points) In muscle, which lacks obvious , Ca2+ enters the cell through Ca2+ channels and binds to on the SR to increase intracellular Ca2+. These ions then bind to , an evolutionary ancestor of troponin C, which activates . This enzyme then phosphorylates one of the two attached to myosin. This phosphorylation changes the position of the so that it can reach the thin filament which is made of polymerized . Contraction in this muscle type ends when an enzyme called a removes the phosphate group that had been added to the answer in Blank #7.