John is a 50-year-old male with a history of systemic hypert…

John is a 50-year-old male with a history of systemic hypertension that has been refractory to medical management. A chest X-ray indicates an enlarged heart. Tim is a 50-year-old male with normal blood pressure. Tim runs 1-2 marathons each year; an X-ray of Tim’s chest also shows an enlarged heart. Given this scenario, choose the correct statement.

A 6-year-old boy presented to his nurse practitioner with a…

A 6-year-old boy presented to his nurse practitioner with a history of easy bruising. He has a brother that died at age 3 of an intracranial hemorrhage after falling off a swing. His mother and father have no history of any type of blood disorder but his maternal grandfather died at age 29 of a bleeding complication after an appendectomy. Which of the following mutations best explains this childs disorder and family history?