Place the following phases of Investigational New Drug (IND) approval in the correct order: 1. The drug is investigated as a treatment for a small number of individuals with the disease the drug is intended to treat. 2. The drug is investigated in large, multicenter studies to establish efficacy and safety. 3. The drug is investigated in small groups of healthy volunteers to establish its activity.

Inhaled aerosols may have which types of intended effects on the body? 1. Enteral 2. Local 3. Systemic 4. Oral

Which of the following routes of drug administration help to reduce the first-pass effect? 1. Oral administration 2. Injection 3. Sublingual tablets 4. Rectal administration

Relaxation of smooth airway muscle in the presence of reversible airflow obstruction is a general indication for the use of: 

Which of the following methods of drug administration requires a needle? 1. Transdermal 2. Inhalation 3. Subcutaneous 4. Intravenous

Which of the following macromolecules is incorrectly matched to its component molecules (i.e., their subunits)?

The psychiatric-mental health nurse practitioner sees a 12-year-old patient who takes lisdexamfetamine (Vyvanse) 50 mg daily for attention-deficit hyperactivity disorder. The nurse practitioner observes a tic, which the parents report began after the patient began taking the psychostimulant, and it has been stable and not interfering with functioning. Both the parents and the school report that the medication is helpful. The nurse practitioner:

If a person is being evaluated for depression and laboratory results show that the patient’s free T4 level is 0.6ng/dL (normal value is 0.8 to 1.5 ng/dL), and the thyroid-stimulating hormone (TSH) is 7.4 U/ml (normal value is 0.4 to 4.0 mIU/L), this suggests the depression:

A 10-year-old female presents with history of major depressive disorder, single episode that was diagnosed approximately 2 year ago. She originally presented with feeling sad and down most days of the week, some irritability, withdrawing to her room often, low self-esteem, and a decrease in interest for activities she typically enjoyed last year. Patient reports she still has some depressed periods but overall her depression has improved over the last year with her current medication regimen. However mother is concerned that within the last 12 months the patient has become increasingly irritable. The patient reports feeling annoyed or irritated almost daily and for most of the day. She has more frequent outbursts of anger in the last couple months and her anger seems to be triggered by minor incidents or being denied something she has requested. Mother also reports when she has her anger outbursts she will destroy property, scream, and slam doors. Majority of outbursts occur at home, but teachers have noted the change in mood and increase in “snapping” or getting angry with peers at school. Would you consider revising her diagnosis? If so, what would you update her working diagnosis list to?

A patient who has been stable on his long-acting injectable medication calls in to let the PMHNP that he would like to quit smoking.  What is the most appropriate response?