Which of the following best describe how genetics was used to catch the Golden State Killer?

   A DNA microarray is used to compare the effects of a new, anti-cancer therapy that reactivates p53. The therapy-treated cancer cells are labeled RED and the untreated, control cancer cells are labeled GREEN. If the therapy is effective, you would expect which of the following with regards to p53 expression:

A couple use chorionic villus sampling because the mother is at risk of a genetic disease. The developing embryo has a karyotype of 46+1 (47), with an extra chromosome. What is the diagnosis? 

Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig’s disease) has over 15 known genes (most likely in a some kind of pathway) that can cause the disease phenotype: a progressive degeneration of nervous system function. This is an example of:

Use the following pedigree for dwarfism to answer the questions below. Based on your understanding of inheritances is the trait dominant or recessive? Is it autosomal or sex-linked? Defend your answers. What is the genotype and phenotype for the following individuals:                        II-1  ___________­­­­­­­­­­­­­­­­­____________               II-3  _______________________     Individual III-4 marries her 1st cousin III-1 (YIKES), and is soon pregnant. After their child is born, they are soon divorced. The husband goes on Jerry Springer. He is furious because they have a ‘tall’ child (not affected) and is accusing his wife of sleeping with his brother (III-3). Is his anger justified? Show your evidence.

Humans display a tremendous amount of variation. It has been postulated that ‘no 2 humans are identical .’ What are two (of the three) ways human genetic variation is increased? Be sure to explain exactly how variation is increased.

When studying a karyotype, how are chromosomes typically arranged (and ordered)?

If the probability of a mother inheriting a disease allele from her parents is 1/2 and the probability that she passes it to her child is 1/4. The chance the child will inherit the allele is 3/4. Assume the males are homozygous normal.

A major difference between the X and Y chromosomes is

During the process of transcription, _____.